WebSep 14, 2024 · STATHMIN-2 is a well-known protein important for neural repair and axonal stability, the expression of which is significantly decreased in the majority of ALS patients. Also known as SCG-10, STMN2 is a protein important for stabilization of microtubules which form an important component of the cytoskeleton of cells and axons. STATHMIN-2 is ... WebMar 29, 2024 · Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be …
Stathmin - an overview ScienceDirect Topics
WebHere, we design and characterize new stathmin-like domain (SLD) proteins that sequester tubulins in numbers different from two, the number of tubulins bound by stathmin or by the SLD of RB3, two stathmin family members that have been extensively studied. We established rules for the design of tight tubulin-SLD assemblies and applied them to ... WebStathmin is a ubiquitously expressed microtubule destabilizing phosphoprotein that is upregulated in a number of cancers. The amino terminus of the protein contains multiple … hartal in hindi
Recombinant Anti-Stathmin 1 (phospho S63) antibody [EPR1574 ... - Abcam
Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell cytoskeleton. Changes in the cytoskeleton are important because the cytoskeleton is a scaffold required for … See more Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), a 78 amino acid coiled-coil region, and a short C-terminal domain. See more The function of Stathmin is to regulate the cytoskeleton of the cell. The cytoskeleton is made up of long hollow cylinders named microtubules. … See more Stathmin's role in regulation of the cell cycle causes it to be an oncoprotein named oncoprotein 18 (op18). Stathmin (aka op18) can cause … See more • Sobel A (August 1991). "Stathmin: a relay phosphoprotein for multiple signal transduction?". Trends in Biochemical Sciences. 16 (8): 301–5. doi:10.1016/0968-0004(91)90123-D. PMID 1957351. • Steinmetz MO (May 2007). "Structure and … See more Stathmin interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex. One mole of stathmin … See more Mice without stathmin have deficiency in innate and learned fear. Stathmin−/− females do not assess threats well, leading to lack of innate parental care and adult social interactions. They lack motivation for retrieving pups and are unable to choose a … See more • NLM • Stathmin.com See more WebMar 26, 2024 · Introduction. Stathmin-2 (encoded by STMN2), has recently been reported as a potential contributor to the pathogenesis of ALS (Klim et al., 2024; Melamed et al., 2024). STMN2, a member of the stathmin family of proteins, encodes a phosphoprotein that has an important role in microtubule dynamics (Cook and Petrucelli, 2024).Microtubules are … WebInvolvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells. Agnieszka Dejda, Philippe Chan, Tommy Seaborn, Laurent Coquet, Thierry Jouenne, Alain Fournier, Hubert Vaudry, David Vaudry. INSERM U982, Institut FÉdÉratif de Recherches Multidisciplinaires sur les Peptides (IFRMP 23), UniversitÉ de Rouen, 76821 Mont-Saint … charley reese final column