WebSep 12, 2024 · Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its anti-proliferative and pro-apoptotic effects on several types of cancer have been well-documented. However, the role of matrine in regulating mitochondrial homeostasis, particularly mitophagy in liver cancer apoptosis, remains uncertain. The aim … WebJun 16, 2024 · Furthermore, PGAM5, which is processed by PARL, participates in PHB2-mediated PINK1 stabilization. Finally, a ligand of PHB proteins that we synthesized, called FL3, was found to strongly inhibit PHB2-mediated mitophagy and to effectively block cancer cell growth and energy production at nanomolar concentrations.
PINK1 drives production of mtDNA-containing …
WebDec 1, 2024 · The most studied is the so-called PINK1/Parkin pathway, which is associated with ubiquitylation of several mitochondrial proteins that were initially found to be related to Parkinson’s disease. Another type of mitophagy is known as receptor-mediated mitophagy, which includes proteins, such as BNIP3 and BNIP3L, also known as Nix. WebMar 11, 2024 · STOML2 restricts full-length PINK1 and mitophagy in pancreatic cancer cells. We further assessed the relationship between STOML2 expression and PINK1-mediated mitophagy. There are many isoforms of PINK1 with different lengths, but only full-length PINK1 (approximately 65 kDa) can functionally recruit Parkin and induce mitophagy . how many roblox hqs are there
PINK1-mediated mitophagy pathway decides the fate of …
WebDec 12, 2024 · Here we show that activation of mGluR3 in breast cancer cells activates Rab27-dependent release of extracellular vesicles (EVs), which can transfer invasive … WebMay 6, 2024 · Oncogene - LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a. ... implications for tumorigenesis, disease progression, and liver cancer stem cells. Mol ... WebDec 14, 2024 · PINK1, human PTEN-induced kinase 1, accumulates when mitochondria are stimulated to cause damage and is then recruited downstream to selectively degrade abnormal mitochondria. Parkin is an E3 ubiquitinated ligase encoded by the PARK2 gene that mainly exists in the cytoplasm and can recognize damaged mitochondria [ 8, 9 ]. how many robloxians are there