WebDescription Pyruvate dehydrogenase deficiency is characterized by the buildup of a chemical called lactic acid in the body and a variety of neurological problems. Signs and symptoms of this condition usually first appear shortly after birth, and they can vary widely among affected individuals. WebThe pyruvate dehydrogenase complex (PDC) 3 catalyzes the oxidative decarboxylation of pyruvate with the formation of acetyl-CoA, CO 2 and NADH (H +) ( 1 , 2 , 3 ). The PDC occupies a key position in the oxidation of glucose by linking the glycolytic pathway to the oxidative pathway of the tricarboxylic acid cycle.
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