WebNov 6, 2015 · Abstract. Chromatin remodelling is critical for repairing DNA damage and maintaining genomic integrity. Previous studies have reported that histone acetyltransferase p300 and ATP-dependent chromatin remodeler chromodomain helicase DNA-binding protein 4 (CHD4) functions, respectively, in DNA double-strand breaks (DSBs) repair. WebChromodomain-helicase-DNA-binding protein 4 (CHD4) is an epigenetic regulator identified as an oncogenic element that may provide a novel therapeutic target for the treatment of breast cancer (BC). CHD4—the core component of the nucleosome remodeling and deacetylase (NuRD) complex—may be mutated in patients with this disease.
CHD8 - Wikipedia
WebWilkinson B, Grepo N, Thompson BL, Kim J, Wang K, Evgrafov OV, Lu W, Knowles JA, Campbell DB. The autism-associated gene chromodomain helicase DNA-binding protein 8 (CHD8) regulates noncoding RNAs and autism-related genes. Transl Psychiatry. 2015 May 19;5(5):e568. doi: 10.1038/tp.2015.62. Citation on PubMed or Free article on … WebIdentifiers Aliases CHD7, CRG, HH5, IS3, KAL5, chromodomain helicase DNA binding protein 7 External IDs OMIM: 608892MGI: 2444748HomoloGene: 19067GeneCards: CHD7 RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in secondary oocyte cerebellar vermis sural nerve inferior ganglion of vagus nerve external globus pallidus raymond boudreau
O97159 - UniProt
WebNov 2, 2010 · Chromodomain-helicase-DNA-binding protein 4 EC number EC:3.6.4.12 ( UniProtKB ENZYME Rhea) 1 publication Short names CHD-4 Alternative names ATP … WebFeb 26, 2024 · R-loops are three-stranded DNA/RNA hybrids that form by the annealing of the mRNA transcript to its coding template while displacing the non-coding strand. While R-loop formation regulates physiological genomic and mitochondrial transcription and DNA damage response, imbalanced R-loop formation can be a threat to the genomic integrity … WebDescription: Homo sapiens chromodomain helicase DNA binding protein 4 (CHD4), mRNA. RefSeq Summary (NM_001273): The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic … simplicity financial services